FDG-PET in colorectal cancer.
FDG-PET in colorectal cancer.
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DOI：
10.1102/1470-7330.2006.9014
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发表时间：
2006-10-31
期刊：
影响因子：
--
通讯作者：
Oyen, Wim J G
中科院分区：
文献类型：
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作者：
de Geus-Oei, Lioe-Fee;Ruers, Theo J M;Oyen, Wim J G
[18 F]氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）是一种有用的成像工具，用于结肠直肠癌患者的治疗。该技术能够测量和可视化癌细胞中的代谢变化。该特征导致区分存活肿瘤与瘢痕组织的能力，导致在比通过常规解剖成像可能的更早阶段检测肿瘤病灶的能力，以及导致测量肿瘤代谢的改变的能力，从而指示肿瘤对治疗的反应。如今，FDG-PET在复发和转移的手术切除前对患者进行分期，在血清癌胚抗原不明原因升高的患者的复发定位以及治疗后残留肿块的评估中发挥着关键作用。在术前评估中，FDG-PET最好与解剖成像结合使用，以便将解剖（CT）和功能（PET）信息的益处联合收割机结合起来，从而显著改善术前肝脏分期和术前对切除可行性的判断。将FDG-PET整合到这些类别患者的管理算法中可以改变和改善治疗管理，降低无效手术导致的发病率，节省大量成本，并可能改善患者结局。FDG-PET在监测介入后不久的局部消融治疗的成功以及预测和评价对放射治疗、全身治疗及其组合的反应方面似乎也具有很大的潜力。本文综述了FDG-PET在结直肠癌诊断中的应用现状和前景。
[18F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a useful imaging tool in the evolving management of patients with colorectal carcinoma. This technique is able to measure and visualize metabolic changes in cancer cells. This feature results in the ability to distinguish viable tumor from scar tissue, in the detection of tumor foci at an earlier stage than possible by conventional anatomic imaging and in the measurement of alterations in tumor metabolism, indicative of tumor response to therapy. Nowadays, FDG-PET plays a pivotal role in staging patients before surgical resection of recurrence and metastases, in the localization of recurrence in patients with an unexplained rise in serum carcinoembryonic antigen and in assessment of residual masses after treatment. In the presurgical evaluation, FDG-PET may be best used in conjunction with anatomic imaging in order to combine the benefits of both anatomical (CT) and functional (PET) information, which leads to significant improvements in preoperative liver staging and preoperative judgment on the feasibility of resection. Integration of FDG-PET into the management algorithm of these categories of patients alters and improves therapeutic management, reduces morbidity due to futile surgery, leads to substantial cost savings and probably also to a better patient outcome. FDG-PET also appears to have great potential in monitoring the success of local ablative therapies soon after intervention and in the prediction and evaluation of response to radiotherapy, systemic therapy, and combinations thereof. This review aims to outline the current and future role of FDG-PET in the field of colorectal cancer.