Obesity Tissue: Composition, Energy Expenditure, and Energy Content in Adult Humans
Obesity Tissue: Composition, Energy Expenditure, and Energy Content in Adult Humans
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DOI：
10.1002/oby.22557
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发表时间：
2019-07-19
期刊：
影响因子：
6.9
通讯作者：
Heymsfield, Steven B.
中科院分区：
文献类型：
--
作者：
Hwaung, Phoenix;Bosy-Westphal, Anja;Heymsfield, Steven B.
目的慢性正能量平衡导致肥胖，超重通常被描述为仅由脂肪组织(AT)或其两个组成部分--脂肪和脱脂物质(非脂肪细胞团、细胞外液)组成。这项研究旨在阐明“肥胖”组织的本质。方法对333例成人的AT、皮肤、骨骼肌、骨、心、肝、肾、脾、脑等部位进行磁共振成像和双能X线骨密度仪测量。首先，通过建立多元回归模型来检验这些成分与AT之间的关系。接下来，通过计算正常体重(BMI<；25 kg/m(2))和肥胖者(BMI>；29.9 kg/m(2))参与者组之间的平均成分质量差，得出肥胖组织组成；计算各自的静息能量消耗以及代谢能量和蛋白质含量。结果在18个多元回归模型中，AT显著预测器官组织质量的有17个。除了AT和骨骼肌之外，还发现了以下关联：皮肤、肝脏和骨骼是肥胖的主要贡献者--组织组成；肝脏、肾脏和心脏是静息能量消耗的主要贡献者；皮肤、肝脏和骨骼是代谢能量和蛋白质含量的主要贡献者。在所有三个模型中都出现了明显的性别二形性。结论肥胖不仅表现为AT过多，还表现为其他“伴发”器官和组织质量及其相关代谢特性的增加。
Objective Chronic positive energy balance leads to obesity, and the "excess" weight is usually described as consisting solely of adipose tissue (AT) or its two components, fat and fat-free mass (nonfat cell mass, extracellular fluid). This study aimed to clarify the nature of "obesity" tissue. Methods A total of 333 adults had AT, skin, skeletal muscle, bone, heart, liver, kidney, spleen, brain, and residual mass measured or derived using magnetic resonance imaging and dual-energy x-ray absorptiometry. First, associations between these components and AT were examined by developing multiple regression models. Next, obesity-tissue composition was developed by deriving mean component mass differences between participant groups with normal weight (BMI < 25 kg/m(2)) and those with obesity (BMI > 29.9 kg/m(2)); respective resting energy expenditures and metabolizable energy and protein contents were calculated. Results AT significantly predicted organ-tissue mass in 17 of 18 multiple regression models. In addition to AT and skeletal muscle, the following associations were found: skin, liver, and bone were main contributors to obesity-tissue composition; liver, kidneys, and heart to resting energy expenditure; and skin, liver, and bone to metabolizable energy and protein contents. A pronounced sexual dimorphism was present in all three models. Conclusions Obesity is characterized not only by excess AT but by increases in the masses of other "companion" organs and tissues and their related metabolic properties.