Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments
Using pupil size and heart rate to infer affective states during behavioral neurophysiology and neuropsychology experiments
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DOI：
10.1016/j.jneumeth.2017.01.004
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发表时间：
2017-03-01
影响因子：
3
通讯作者：
Murray, Elisabeth A.
中科院分区：
文献类型：
--
作者：
Mitz, Andrew R.;Chacko, Ravi V.;Murray, Elisabeth A.
背景资料：非人灵长类动物（NHP）是一个有价值的研究模型，因为它们的行为，生理和神经解剖学与人类相似。在没有语言的情况下，自主活动可以提供关键信息的认知和情感状态，在单单位记录，失活和病变studies.Methods标准化用于人类不容易适应NHPs和详细的指导一直缺乏。新方法：我们通过解决NHP研究的方法学问题、陷阱和解决方案，为在行为神经生理学环境中监测心率和瞳孔大小提供指导。这些方法基于比较生理学，以确定每种溶液的原理。我们包括从两个电生理和病变study.Results的例子：单单位记录，瞳孔反应和心率的变化代表了一个范围内的时间分辨率下降，影响实验设计和分析的特点。我们证明了意想不到的结果，杏仁核病变前后获得的自主神经措施是可比的，尽管正常的自主神经功能中断。与现有方法的比较：种属和研究设计差异可能导致人体研究中使用的标准技术不适用于NHP研究。我们展示了如何管理数据，从典型的NHP研究小组，从短期行为试验典型的神经生理学研究，与纵向研究相关的问题，并在解剖学和生理学的差异。结论：自主测量推断认知和情感状态NHP既不是现成的，也不繁重。熟悉的问题和解决方案将扩大自主神经信号的使用NHP单单位和病变的研究。由爱思唯尔公司出版
Background: Nonhuman primates (NHPs) are a valuable research model because of their behavioral, physiological and neuroanatomical similarities to humans. In the absence of language, autonomic activity can provide crucial information about cognitive and affective states during single-unit recording, inactivation and lesion studies.Methods standardized for use in humans are not easily adapted to NHPs and detailed guidance has been lacking. New method: We provide guidance for monitoring heart rate and pupil size in the behavioral neurophysiology setting by addressing the methodological issues, pitfalls and solutions for NHP studies. The methods are based on comparative physiology to establish a rationale for each solution. We include examples from both electrophysiological and lesion studies.Results: Single-unit recording, pupil responses and heart rate changes represent a range of decreasing temporal resolution, a characteristic that impacts experimental design and analysis. We demonstrate the unexpected result that autonomic measures acquired before and after amygdala lesions are comparable despite disruption of normal autonomic function. Comparison with existing methods: Species and study design differences can render standard techniques used in human studies inappropriate for NHP studies. We show how to manage data from small groups typical of NHP studies, data from the short behavioral trials typical of neurophysiological studies, issues associated with longitudinal studies, and differences in anatomy and physiology.Conclusions: Autonomic measurement to infer cognitive and affective states in NHP is neither off-the shelf nor onerous. Familiarity with the issues and solutions will broaden the use of autonomic signals in NHP single unit and lesion studies. Published by Elsevier B.V.