The regulatory role of Valpha14 NKT cells in innate and acquired immune response.
The regulatory role of Valpha14 NKT cells in innate and acquired immune response.
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发表时间：
2003
影响因子：
29.7
通讯作者：
M. Taniguchi;M. Harada;S. Kojo;T. Nakayama;H. Wakao
中科院分区：
文献类型：
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作者：
M. Taniguchi;M. Harada;S. Kojo;T. Nakayama;H. Wakao
一种新的淋巴细胞系，Valpha14自然杀伤T(NKT)细胞，现在已经被很好地建立起来，与传统的Alphabeta T细胞不同。Valpha14 NKT细胞表达单一不变的Valpha14抗原受体，对其发育至关重要。α-半乳糖基神经酰胺(α-GalCer)的成功鉴定和Valpha14 NKT细胞选择性缺失的基因操纵小鼠的建立，有助于阐明Valpha14 NKT细胞在多种免疫反应中显著的功能多样性，如通过介导抗非自身天然免疫反应、抗自身反应的动态平衡调节和抗肿瘤免疫来实现宿主防御。
A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.