ORAL POLIO VACCINATION OF CHILDREN IN TROPICS .3. INTERCURRENT ENTEROVIRUS INFECTIONS, VACCINE VIRUS TAKE AND ANTIBODY-RESPONSE
ORAL POLIO VACCINATION OF CHILDREN IN TROPICS .3. INTERCURRENT ENTEROVIRUS INFECTIONS, VACCINE VIRUS TAKE AND ANTIBODY-RESPONSE
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DOI：
10.1093/oxfordjournals.aje.a112181
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发表时间：
1975-01-01
影响因子：
5
通讯作者：
CHRISTOPHER, S
中科院分区：
文献类型：
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作者：
JOHN, TJ;CHRISTOPHER, S
John, T. J.（亚利桑那大学医学中心儿科系，图森，AZ 85724）和 S. Christopher。热带地区儿童的口服脊髓灰质炎疫苗接种。三．并发肠道病毒感染、疫苗病毒摄入和抗体反应。Am J Epidemiol102:422–428, 1975。在没有一种、两种或三种脊髓灰质炎病毒血清型抗体的婴儿和儿童群体中研究了并发肠道病毒感染对口服脊髓灰质炎疫苗 (OPV) 宿主反应的影响。每周收集并接种于原代猴肾细胞培养物、HEp 2 细胞和新生小鼠的粪便标本中检测到肠道病毒感染的患病率在 60% 至 70% 之间。在施用 OPV 时、之前 1 周或之前 3 周期间存在此类感染似乎不会抑制疫苗病毒吸收或抗体反应。然而，在受感染和未受感染的儿童中，疫苗病毒的接种率和血清转化率均明显低于几个温带气候国家报告的水平。
John, T. J. (Dept. of Pediatrics. Univ. of Arizona Med. Ctr., Tucson, AZ 85724), and S. Christopher. Oral polio vaccination of children in the tropics. III. Intercurrent enterovirus infections, vaccine virus take and antibody response.Am J Epidemiol102:422–428, 1975.The effect of intercurrent enterovirus infections on host responses to oral polio vaccine (OPV) was studied in groups of infants and children who were without antibodies to one, two or three serotypes of poliovirus. The prevalence of enterovirus infections as detected in fecal specimens collected at weekly intervals and inoculated in primary monkey kidney cell culture, HEp 2 cells and newborn mice ranged between 60 and 70 per cent. The presence of such infections at the time of, 1 week prior to, or during the 3 weeks prior tothe administration of OPV did not appear to inhibit either vaccine virus take or antibodyresponse. However, in both the infected and uninfected children the rates of vaccine virus take and seroconversion were found to be considerably lower than those reported from several temperate climate countries.