New model for the interaction of IQGAP1 with CDC42 and RAC1.
New model for the interaction of IQGAP1 with CDC42 and RAC1.
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DOI：
10.1080/21541248.2017.1321169
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Ahmadian, Mohammad R
中科院分区：
文献类型：
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作者：
Nouri, Kazem;Timson, David J;Ahmadian, Mohammad R
涉及IQGAP家族蛋白质的蛋白质复合物的特异性和快速形成对于多种细胞过程（例如粘附、极化和定向迁移）是必不可少的。虽然CDC 42和RAC 1是RHO GT3家族的重要成员，它们与IQGAP 1的结合和激活有关，但这种蛋白质-蛋白质识别过程的确切性质仍然不清楚。在这里，我们提出了一个机制框架模型，该模型是基于一个多步骤的结合过程，这是一个先决条件的IQGAP 1作为一个支架蛋白和时间调节和整合的细胞通路的关键机制的动态功能。
The specific and rapid formation of protein complexes, involving IQGAP family proteins, is essential for diverse cellular processes, such as adhesion, polarization, and directional migration. Although CDC42 and RAC1, prominent members of the RHO GTPase family, have been implicated in binding to and activating IQGAP1, the exact nature of this protein-protein recognition process has remained obscure. Here, we propose a mechanistic framework model that is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation and integration of cellular pathways.