Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats.
Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats.
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DOI：
10.1016/s0272-6386(12)80631-7
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发表时间：
1991-04
期刊：
影响因子：
--
通讯作者：
Saeed R. Khan
中科院分区：
文献类型：
--
作者：
Saeed R. Khan
大鼠草酸钙（CaOx）尿石症是通过产生高草酸尿而诱发的。根据高草酸尿症的程度和持续时间，CaOx 晶体可能在肾单位或膀胱中形成，并且可能会或可能不会保留在肾脏中。晶体可能在肾单位的一部分成核并保留在另一部分。乳头状集合管管状上皮及其基底膜似乎参与晶体在肾脏中的滞留。
Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria. Depending on the degree and length of hyperoxaluria, CaOx crystals may either form in the nephron or the bladder and may or may not be retained in the kidneys. Crystals may nucleate in one part of the nephron and be retained in another part. Papillary collecting duct tubular epithelium and its basement membrane appear to be involved in crystal retention in the kidneys.