TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
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DOI：
10.1196/annals.1447.034
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Greiner DL
中科院分区：
文献类型：
--
作者：
Miller DM;Thornley T;Pearson T;Yamazaki M;Brehm MA;Rossini AA;Greiner DL
We investigated the mechanisms by which toll-like receptor (TLR) agonists affect the induction of mixed chimerism and skin allograft survival in mice treated with costimulation blockade (CB). We report that TLR agonists prevent the generation of mixed chimerism by breaking tolerance in the alloreactive CD4+ and CD8+ T cell compartments, and that type I interferon (IFN) is important in this process. Understanding how environmental perturbations affect CB-induced transplantation tolerance may lead to more effective regimens that can be used as an approach for the treatment of type 1 diabetes, for which the transplantation of pancreatic islets is a promising therapy.
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影响因子：
15.9
作者：
Seung, E;Mordes, JP;Greiner, DL
通讯作者：
Greiner, DL
影响因子：
4.4
作者：
Thornley, TB;Brehm, MA;Greiner, DL
通讯作者：
Greiner, DL
影响因子：
3.2
作者：
Thorburn, Megan S.;Vistisen, Bodil;Rowlands, David S.
通讯作者：
Rowlands, David S.
影响因子：
8.8
作者：
Yamazaki, M.;Pearson, T.;Greiner, D. L.
通讯作者：
Greiner, D. L.