Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain.

Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain.
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中枢神经系统疾病中的线粒体细胞外囊泡:了解脑神经系统疾病的新前沿。

DOI:
10.3389/fmolb.2022.840364
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发表时间:
2022
影响因子:
5
通讯作者:
--
中科院分区:
生物学3区
文献类型:
--
作者:

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最近的研究结果强调了含有线粒体衍生组分的细胞外囊泡(EV)对神经系统疾病的潜在诊断和预后价值。此外,已经报道了携带线粒体组分的囊泡的功能影响。特别是,这包括与线粒体自噬的串扰影响各种CNS疾病进展的适应症。在这篇小型综述中,我们讨论了目前关于CNS神经系统疾病中这类有趣的囊泡的知识状况,并概述了这一迷人研究领域的空白和进一步发展的范围。
Recent findings have highlighted potential diagnostic and prognostic values of extracellular vesicles (EVs) that contain mitochondrial derived components for neurological disorders. Furthermore, functional influences of vesicles carrying mitochondrial components have been reported. In particular, this includes indications of crosstalk with mitophagy to influence progression of various CNS disorders. In this mini-review, we discuss the current state of knowledge about this intriguing class of vesicles in neurological disorders of the CNS, and outline the lacunae and thus scope of further development in this fascinating field of study.
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