Normal human aging and early-stage schizophrenia share common molecular profiles.
Normal human aging and early-stage schizophrenia share common molecular profiles.
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DOI：
10.1111/j.1474-9726.2009.00468.x
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发表时间：
2009-06
期刊：
影响因子：
7.8
通讯作者：
Thomas EA
中科院分区：
文献类型：
--
作者：
Tang B;Chang WL;Lanigan CM;Dean B;Sutcliffe JG;Thomas EA
We examined genome-wide expression datasets from human frontal cortex of normal and schizophrenic individuals ranging from 19 to 81 years of age. We found that changes in gene expression that are correlated with aging in normal subjects differ dramatically from those observed with aging in schizophrenic subjects. Only 2.5% of genes were correlated with age in both groups. Surprisingly, we also found a significant overlap (29−34%) between those genes whose expression was correlated with aging in normal subjects and those significantly altered in subjects with early-stage schizophrenia (within 4 years of diagnosis). This suggests that schizophrenia onset anticipates the normal aging process, and further, that some symptoms of aging, i.e. dementia and psychosis, might be explained by these common molecular profiles.
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影响因子：
2.9
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Narayan S;Tang B;Head SR;Gilmartin TJ;Sutcliffe JG;Dean B;Thomas EA
通讯作者：
Thomas EA
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10.6
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