Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder.
Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder.
复制标题
主扣皮皮层活性和重度抑郁症治疗期间的早期症状改善。
DOI：
10.1016/j.pscychresns.2010.12.007
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发表时间：
2011-06-30
影响因子：
2.3
通讯作者：
Leuchter, Andrew F.
中科院分区：
文献类型：
--
作者：
Korb, Alexander S.;Hunter, Aimee M.;Cook, Ian A.;Leuchter, Andrew F.
In treatment trials for Major Depressive Disorder (MDD), early symptom improvement is predictive of eventual clinical response. Clinical response may also be predicted by elevated pretreatment theta (4-7 Hz) current density in the rostral anterior cingulate (rACC) and medial orbitofrontal cortex (mOFC). We investigated the relationship between pretreatment EEG and early improvement in predicting clinical outcome in 72 MDD subjects across three placebo-controlled treatment trials. Subjects were randomized to receive fluoxetine, venlafaxine, or placebo. Theta current density in the rACC and mOFC was computed with Low-Resolution Brain Electromagnetic Tomography (LORETA). An ANCOVA, examining week 8 Hamilton Depression Rating Scale (HamD) percent change, showed a significant effect of week-2-HamD-percent-change, and a significant three-way interaction of week-2-HamD-percent-change × Treatment × rACC. Medication subjects with robust early improvement showed almost no relationship between rACC theta current density and final clinical outcome. However, in subjects with little early improvement, rACC activity showed a strong relationship with clinical outcome. The model examining mOFC showed a trend in the three-way interaction. A combination of pretreatment rACC activity and early symptom improvement may be useful for predicting treatment response.
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影响因子：
2.3
作者：
Brody, AL;Saxena, S;Baxter, LR
通讯作者：
Baxter, LR
影响因子：
17.7
作者：
Hunter, Aimee M.;Leuchter, Andrew F.;Cook, Ian A.
通讯作者：
Cook, Ian A.
影响因子：
3.4
作者：
Leuchter, AF;Morgan, M;Witte, E
通讯作者：
Witte, E
影响因子：
7.6
作者：
Katz, MM;Tekell, JL;Frazer, A
通讯作者：
Frazer, A
影响因子：
5.3
作者：
Kong, J;Gollub, RL;Kaptchuk, TJ
通讯作者：
Kaptchuk, TJ