Corticotropin-releasing factor-like activity in human placental extracts.
Corticotropin-releasing factor-like activity in human placental extracts.
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DOI：
10.1210/jcem-55-2-384
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发表时间：
1982-08
期刊：
影响因子：
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通讯作者：
T. Shibasaki;E. Odagiri;K. Shizume;N. Ling
中科院分区：
文献类型：
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作者：
T. Shibasaki;E. Odagiri;K. Shizume;N. Ling
促肾上腺皮质激素释放因子（CRF）样活性，这是第一次发现在下丘脑，检测到在足月的人胎盘提取物从自然分娩。胎盘CRF样物质的分子大小略大于促肾上腺皮质激素。在培养的大鼠垂体前叶细胞中，胎盘CRF样物质在促肾上腺皮质激素和β-内啡肽的释放方面显示出与部分纯化的大鼠下丘脑CRF和人工合成的绵羊CRF相似的生物活性。此外，胰蛋白酶消化人胎盘CRF样活性减弱。因此，人类胎盘可能精心制作类似于下丘脑CRF的物质。
Corticotropin-releasing factor (C R F)-like activity, which was first found in the hypothalamus, was detected in the extracts of human placentas obtained at full term from spontaneous deliveries. The molecular size of the placental CRF-like substance is slightly larger than that of adrenocorticotropin. In cultures of rat anterior pituitary cells, the placental CRF-like material shows bioactivity similar to that of the partially purified rat hypothalamic CRF and synthetic ovine C R F on the release of adrenocorticotropin and (β-endorphin. Furthermore, the CRF-like activity from human placenta was attenuated by trypsin digestion. Thus the human placenta may elaborate a substance similar to hypothalamic CRF.