Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones
Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones
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DOI：
10.1021/ol801259u
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发表时间：
2008-08-21
期刊：
影响因子：
5.2
通讯作者：
Hayashi, Masahiko
中科院分区：
文献类型：
--
作者：
Kawamura, Kenjiro;Fukuzawa, Hitomi;Hayashi, Masahiko
使用0.25mol%的含有2-喹啉基部分的N，N，P-三齿配体（1和2）和0.1mol%的Cu（OTf）（2）能够使二烷基锌与环烯酮的对映选择性1，4-加成以高达99%ee产生1，4-加合物。
Use of 0.25 mol % of the N,N,P-tridentate ligand containing the 2-quinolyl moiety (1 and 2) and 0.1 mol % of Cu(OTf)(2) enabled the enantioselective 1,4-addition of dialkylzincs to cyclic enones to produce 1,4-adducts in up to 99% ee.