Dietary patterns and risk of dementia - The three-city cohort study
Dietary patterns and risk of dementia - The three-city cohort study
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DOI：
10.1212/01.wnl.0000278116.37320.52
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发表时间：
2007-11-13
期刊：
影响因子：
9.9
通讯作者：
Alperovitch, A.
中科院分区：
文献类型：
--
作者：
Barberger-Gateau, P.;Raffaitin, C.;Alperovitch, A.
背景：膳食脂肪酸和抗氧化剂可能有助于降低痴呆风险，但流行病学数据仍存在争议。本研究的目的是分析饮食模式与痴呆或阿尔茨海默病（AD）风险之间的关系，调整社会人口统计学和血管风险因素，并考虑ApoE基因型。在波尔多、第戎戎、1999-2000年在法国蒙彼利埃进行了随访，随访率为89.1%。一个独立的神经学家委员会验证了281例痴呆症（包括183例AD）的发病率。结果：在完全校正的模型中，每天食用水果和蔬菜与全因痴呆症的风险降低相关（风险比[HR] 0.72，95%CI 0.53至0.97）。每周食用鱼与AD（HR 0.65，95% CI 0.43至0.994）和所有原因痴呆的风险降低相关，但仅在ApoE 4非携带者中（HR 0.60，95% CI 0.40至0.90）。经常使用富含omega-3的油与降低所有原因痴呆的临界显著性风险相关（HR 0.46，95% CI 0.19至1.11）。经常食用富含omega-6的油而不食用富含omega-3的油或鱼与痴呆症风险增加有关（HR 2.12，95%CI 1.30 - 3.46）。结论：经常食用水果和蔬菜，鱼和富含欧米茄-3的油可以降低患痴呆症和阿尔茨海默病的风险，尤其是ApoE（ApoE）4非携带者。
Background: Dietary fatty acids and antioxidants may contribute to decrease dementia risk, but epidemiologic data remain controversial. The aim of our study was to analyze the relationship between dietary patterns and risk of dementia or Alzheimer disease (AD), adjusting for sociodemographic and vascular risk factors, and taking into account the ApoE genotype.Methods: A total of 8,085 nondemented participants aged 65 and over were included in the Three-City cohort study in Bordeaux, Dijon, and Montpellier (France) in 1999-2000 and had at least one re-examination over 4 years (rate of follow-up 89.1%). An independent committee of neurologists validated 281 incident cases of dementia (including 183 AD).Results: Daily consumption of fruits and vegetables was associated with a decreased risk of all cause dementia (hazard ratio [HR] 0.72, 95% Cl 0.53 to 0.97) in fully adjusted models. Weekly consumption of fish was associated with a reduced risk of AD (HR 0.65, 95% Cl 0.43 to 0.994) and all cause dementia but only among ApoE 4 noncarriers (HR 0.60, 95% Cl 0.40 to 0.90). Regular use of omega-3 rich oils was associated with a decreased risk of borderline significance for all cause dementia (HR 0.46, 95% Cl 0.19 to 1.11). Regular consumption of omega-6 rich oils not compensated by consumption of omega-3 rich oils or fish was associated with an increased risk of dementia (HR 2.12, 95% Cl 1.30 to 3.46) among ApoE (epsilon)4 noncarriers.Conclusion: Frequent consumption of fruits and vegetables, fish, and omega-3 rich oils may decrease the risk of dementia and Alzheimer disease, especially among ApoE (epsilon)4 noncarriers.