Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices
Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices
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DOI：
10.1038/srep04133
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发表时间：
2014-02-26
影响因子：
4.6
通讯作者：
Voudris, Vassilis
中科院分区：
文献类型：
--
作者：
Farsalinos, Konstantinos E.;Spyrou, Alketa;Voudris, Vassilis
各种各样的电子烟（EC）装置，从小型的类似香烟（第一代）到新一代的高容量电池，其电子电路为可再填充的雾化器提供高能量，可供吸烟者替代吸烟。尼古丁输送到血液中对于确定EC的成瘾性很重要，但也是它们作为吸烟替代品的功效。在本研究中，使用第一代与新一代EC装置，使用含18 mg/ml尼古丁的液体，持续1小时，测量有经验用户的血浆尼古丁水平。与第一代设备相比，使用新设备时血浆尼古丁水平高出35-72%。与吸一根香烟相比，本研究中使用的EC装置和液体在使用5分钟后提供了三分之一到四分之一的尼古丁量。新一代EC装置在尼古丁递送方面更有效，但与烟草卷烟相比，递送尼古丁的速度仍然慢得多。使用18 mg/ml尼古丁浓度的液体可能会损害EC作为吸烟替代品的有效性;本研究支持需要更高水平的含尼古丁液体（约50 mg/ml），以更有效地递送尼古丁并接近烟草卷烟的尼古丁递送特征。
A wide range of electronic cigarette (EC) devices, from small cigarette-like (first-generation) to new-generation high-capacity batteries with electronic circuits that provide high energy to a refillable atomizer, are available for smokers to substitute smoking. Nicotine delivery to the bloodstream is important in determining the addictiveness of ECs, but also their efficacy as smoking substitutes. In this study, plasma nicotine levels were measured in experienced users using a first-vs. new-generation EC device for 1 hour with an 18 mg/ml nicotine-containing liquid. Plasma nicotine levels were higher by 35-72% when using the new-compared to the first-generation device. Compared to smoking one tobacco cigarette, the EC devices and liquid used in this study delivered one-third to one-fourth the amount of nicotine after 5 minutes of use. New-generation EC devices were more efficient in nicotine delivery, but still delivered nicotine much slower compared to tobacco cigarettes. The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes.