Simultaneous Whole-Body PET/MR Imaging in Comparison to PET/CT in Pediatric Oncology: Initial Results
Simultaneous Whole-Body PET/MR Imaging in Comparison to PET/CT in Pediatric Oncology: Initial Results
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DOI：
10.1148/radiol.14131732
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发表时间：
2014-10-01
期刊：
影响因子：
19.7
通讯作者：
Schwenzer, Nina F.
中科院分区：
文献类型：
--
作者：
Schaefer, Juergen F.;Gatidis, Sergios;Schwenzer, Nina F.
目的：比较正电子发射断层扫描(PET)/磁共振(MR)成像和正电子发射断层扫描(PET)/计算机断层扫描(CT)在儿童实体肿瘤患者中的病变检测和解释、18氟脱氧葡萄糖(FDG)摄取的量化以及基于MR的PET衰减校正的准确性。材料和方法：这项前瞻性研究得到了当地伦理委员会和德国联邦药物和医疗器械研究所的批准。获得所有患者和法定监护人的书面知情同意。对18例患儿进行了20次全身F-18-FDG PET/CT和F-18-FDG PET/MR检查，年龄11~17岁，中位数14岁。在同一天连续采集所有患者的F-18-FDG PET/CT和F-18-FDG PET/MR数据。在病变和健康组织中，用感兴趣体积测量来量化PET标准摄取值(SUV)。比较基于MR的PET衰减校正和CT的衰减图(MU-MAP)。通过分别读取PET/CT和PET/MR数据来评估病变检测。根据F-18-FDG的应用剂量和CT方案参数估算辐射剂量。结果：PET/CT的PET/CT(PETCT)和PET/MR(PETMR)的PET之间有很强的相关性(r>；0.85，对于大多数组织)。除了骨结构和肺部基于MR的PET衰减校正的缺点外，在基于CT的MU-MAP校正的PET图像上也发现了类似的SUV(骨髓和
Purpose: To compare positron emission tomography (PET)/magnetic resonance (MR) imaging and PET/computed tomography (CT) for lesion detection and interpretation, quantification of fluorine 18 (F-18) fluorodeoxyglucose (FDG) uptake, and accuracy of MR-based PET attenuation correction in pediatric patients with solid tumors.Materials and Methods: This prospective study had local ethics committee and German Federal Institute for Drugs and Medical Devices approval. Written informed consent was obtained from all patients and legal guardians. Twenty whole-body F-18-FDG PET/CT and F-18-FDG PET/MR examinations were performed in 18 pediatric patients (median age, 14 years; range, 11-17 years). F-18-FDG PET/CT and F-18-FDG PET/MR data were acquired sequentially on the same day for all patients. PET standardized uptake values (SUVs) were quantified with volume of interest measurements in lesions and healthy tissues. MR-based PET attenuation correction was compared with CT-derived attenuation maps (mu-maps). Lesion detection was assessed with separate reading of PET/CT and PET/MR data. Estimates of radiation dose were derived from the applied doses of F-18-FDG and CT protocol parameters. Descriptive statistical analyses were performed to report correlation coefficients and relative deviations for comparison of SUVs, rates of lesion detection, and percentage reductions in radiation dose.Results: PET SUVs showed strong correlations between PET of PET/CT (PETCT) and PET of PET/MR (PETMR) (r > 0.85 for most tissues). Apart from drawbacks of MR-based PET attenuation correction in osseous structures and lungs, similar SUVs were found on PET images corrected with CT-based mu-maps (13.1% deviation of SUVs for bone marrow and