IMMUNOGLOBULIN HEAVY-CHAIN BINDING-PROTEIN
IMMUNOGLOBULIN HEAVY-CHAIN BINDING-PROTEIN
复制标题
DOI：
10.1038/306387a0
复制
发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
WABL, M
中科院分区：
文献类型：
--
作者：
HAAS, IG;WABL, M
前b淋巴细胞及其衍生的杂交瘤在缺乏轻(L)链的情况下合成免疫球蛋白重（IgH）链1。在Abelson病毒转化的细胞系18-81中，我们观察到至少一些h链与l链以外的蛋白质结合。在这里，我们发现这种蛋白（我们称之为免疫球蛋白重链结合蛋白，BiP）与游离的IgH非共价结合，但不与与IgL相关的IgH结合。
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain1. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.