LATERALIZED EFFECTS OF MONOCULAR TRAINING ON DENDRITIC BRANCHING IN ADULT SPLIT-BRAIN RATS
LATERALIZED EFFECTS OF MONOCULAR TRAINING ON DENDRITIC BRANCHING IN ADULT SPLIT-BRAIN RATS
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DOI：
10.1016/0006-8993(82)90274-8
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
GREENOUGH, WT
中科院分区：
文献类型：
--
作者：
CHANG, FLF;GREENOUGH, WT
许多实验方法表明，在发育和成年期间经历不同的经历后，神经元之间的连接存在差异。在高尔基体制备物中，据报道，长时间的迷宫训练会改变成年大鼠枕叶皮层第四层和第五层锥体神经元远端树突的树突分支。为了确定这种效应对直接参与训练的视觉方面的特异性，本研究检查了使用裂脑程序和不透明接触遮挡器的单眼迷宫训练的效果。对大鼠进行单侧或交替单眼闭塞的迷宫训练，而对未经训练的单侧或交替单眼闭塞的大鼠进行简单处理并给予水奖励。在未经训练的对照中，固定封堵器位置没有产生动物内效应。在单侧闭塞训练的大鼠中，与睁开眼睛相对的枕叶皮质中的第五层锥体神经元在顶端树突远端区域的倾斜树突长度比闭塞眼睛相对的那些神经元更长。同样，经过交替闭塞训练的大鼠在第五层枕锥体神经元中的远端顶端倾斜树突长度比未经训练的对照组更大。这表明训练的形态后遗症集中在处理与训练的视觉方面相关的信息的区域，并且不太可能是这种效应的一般代谢或激素因果关系。
A number of experimental approaches have indicated differential interneuronal connectivity following differential experience during both development and adulthood. In Golgi preparations, prolonged maze training was reported to alter dendritic branching of distal apical dendrites of Layer IV and V pyramidal neurons in adult rat occipital cortex. To determine the specificity of this effect to direct involvement in the visual aspects of training, the effects of monocular maze training, using a split-brain procedure and opaque contact occluders, was examined in the present study. Rats were maze trained with unilateral or alternating monocular occlusion, while non-trained rats with unilateral or alternating monocular occlusion were handled briefly and given water reward. There was no within-animal effect of fixed occluder position in non-trained controls. In unilaterally-occluded trained rats, Layer V pyramidal neurons in occipital cortex opposite the open eye had greater oblique dendritic length in the distal region of the apical dendrite than did those opposite the occluded eye. Similarly, rats trained with alternating occlusion had greater distal apical oblique dendritic length in Layer V occipital pyramidal neurons than did non-trained controls. This indicates that morphological sequelae of training are concentrated in areas processing information associated with visual aspects of the training and renders unlikely general metabolic or hormonal causation of such effects.