A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging
A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging
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DOI：
10.1093/gerona/glz057
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发表时间：
2019-11-01
影响因子：
5.1
通讯作者：
Hofer, Scott M.
中科院分区：
文献类型：
--
作者：
Duggan, Emily C.;Piccinin, Andrea M.;Hofer, Scott M.
背景资料：大量的研究致力于了解与衰老相关的动态之间的水平，变化和变化的个体差异，在身体和认知能力。评估可复制性和综合这些发现受到测量和样本差异的限制，并受到研究设计和统计分析的限制，这些分析混淆了人与人之间的差异和人内变化。在这篇文章中，我们进行了协调分析和汇总荟萃分析的新结果与年龄相关的动力学连接肺功能和认知performance.Methods：我们进行了协调分析的二元增长模型的数据从20,586名参与者在8个纵向研究，以检查个体差异的基线水平，变化率，以及特定的变异性肺和认知功能。结果进行了总结，使用meta analysis.Results：我们发现一致的，但弱基线和纵向协会在肺和认知功能的水平，但没有协会在approximation特定variability.Conclusions：结果提供了有限的证据，肺和认知功能的同时变化在正常老龄化人群之间的一致联系。需要进一步研究，以了解衰退的发病模式以及身体和认知功能领域内部和之间的变化率差异，包括个人内部和国家之间以及出生队列之间。协调分析提供了一种有效和严格的方法，用于复制和比较独立纵向研究的结果。
Background: Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this article, we conducted a coordinated analysis and summary meta-analysis of new results on the aging-related dynamics linking pulmonary function and cognitive performance.Methods: We performed coordinated analysis of bivariate growth models in data from 20,586 participants across eight longitudinal studies to examine individual differences in baseline level, rate of change, and occasion-specific variability in pulmonary and cognitive functioning. Results were summarized using meta-analysis.Results: We found consistent but weak baseline and longitudinal associations in levels of pulmonary and cognitive functioning, but no associations in occasion-specific variability.Conclusions: Results provide limited evidence for a consistent link between simultaneous changes in pulmonary and cognitive function in a normal aging population. Further research is required to understand patterns of onset of decline and differences in rates of change within and across physical and cognitive functioning domains, both within-individuals and across countries and birth cohorts. Coordinated analysis provides an efficient and rigorous approach for replicating and comparing results across independent longitudinal studies.