Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow.
Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow.
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DOI：
10.1117/1.jbo.21.3.036005
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发表时间：
2016-03
影响因子：
3.5
通讯作者：
Wang RK
中科院分区：
文献类型：
--
作者：
Wei W;Xu J;Baran U;Song S;Qin W;Qi X;Wang RK
我们通过使用 1.6 MHz 傅立叶域锁模扫频源光学相干断层扫描和有效的 36 kHz 微机电系统 (MEMS) 扫描仪演示体内体积光学微血管造影。我们提出了一种体间分析策略来对比静态组织背景的动态血流信号。通过对小鼠体内脑血流进行成像来证明所提出的系统。成像速度、灵敏度和时间分辨率首次成为对活体身体部位内微循环进行直接四维观察的可能。
We demonstrate in vivo volumetric optical microangiography at by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo. For the first time, imaging speed, sensitivity, and temporal resolution become possible for a direct four-dimensional observation of microcirculations within live body parts.