INTERLEUKIN 6 - A POTENTIAL MEDIATOR OF LETHAL SEPSIS AFTER MAJOR THERMAL TRAUMA - EVIDENCE FOR INCREASED IL-6 PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS
INTERLEUKIN 6 - A POTENTIAL MEDIATOR OF LETHAL SEPSIS AFTER MAJOR THERMAL TRAUMA - EVIDENCE FOR INCREASED IL-6 PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS
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DOI：
10.1097/00005373-199112000-00017
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发表时间：
1991-12-01
影响因子：
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通讯作者：
KONIG, W
中科院分区：
文献类型：
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作者：
SCHLUTER, B;KONIG, B;KONIG, W
我们研究了21例严重烧伤患者（烧伤面积为24%至75%体表面积）的急性期介质白细胞介素6（IL-6）的血浆水平。创伤后血浆IL-6水平的变化与临床预后密切相关。非脓毒症幸存者以及疑似脓毒症幸存者（n = 14）在烧伤后的前3天内表现出最大量的IL-6（251 +/- 32 pg/mL），随后恢复到正常范围内的值（第30至50天; 26 +/- 8 pg/mL）。在非存活者（n = 7）中，IL-6浓度永久性地增加（高达1，921 +/- 356 pg/mL），直至死亡（第10至19天），其由脓毒症伴连续多器官衰竭引起。与健康供体的PBMC相比，患者的外周血单核细胞（PBMC）在体内以高水平表达IL-6特异性mRNA。此外，与健康对照组相比，患者PBMC的自发和PHA诱导的体外IL-6产生增强，而细菌内毒素（LPS）无显著差异。研究结果表明，白细胞介素6是一个潜在的介质致命败血症后，重大热创伤。
We studied the plasma levels of the acute phase mediator interleukin 6 (IL-6) in 21 severely burned patients (burn injuries ranging from 24% to 75% total body surface area). The posttraumatic course of the IL-6 plasma levels was closely related to the clinical outcome. The nonseptic survivors as well as survivors with suspected sepsis (n = 14) exhibited maximal amounts of IL-6 (251 +/- 32 pg/mL) during the first 3 days post-burn, which subsequently returned to values within the normal range (days 30 to 50; 26 +/- 8 pg/mL). In the nonsurvivors (n = 7) IL-6 concentrations permanently increased (up to 1,921 +/- 356 pg/mL) until death (days 10 to 19) resulting from sepsis with consecutive multiple organ failure. Peripheral blood mononuclear cells (PBMCs) of patients expressed IL-6-specific mRNA in vivo at high levels in contrast to the PBMCs of healthy donors. In addition, the spontaneous and PHA-induced in vitro production of IL-6 by patients' PBMCs was enhanced compared with healthy controls, whereas no significant differences were obtained with bacterial endotoxin (LPS). The findings suggest that interleukin 6 is a potential mediator of lethal sepsis after major thermal trauma.