Effects of nucleus accumbens insulin inactivation on microstructure of licking for glucose and saccharin in male and female rats.
Effects of nucleus accumbens insulin inactivation on microstructure of licking for glucose and saccharin in male and female rats.
复制标题
胰岛素失活对雌雄大鼠舔葡萄糖和糖精微结构的影响。
DOI：
10.1016/j.physbeh.2022.113769
复制
发表时间：
2022-05-15
影响因子：
2.9
通讯作者：
Weiner SP
中科院分区：
文献类型：
--
作者：
Carr KD;Weiner SP
胰腺来源的胰岛素进入大脑，其中几个区域表达高密度的胰岛素受体。脑胰岛素信号传导的功能研究主要集中在下丘脑对食欲的调节和海马对学习的调节。最近的研究指出，在葡萄糖摄入的饮食敏感性反应和加强风味营养学习的参与核（NAc）胰岛素信号。本研究使用NAc壳微量注射胰岛素灭活抗体（InsAb），以评估风味6.1%葡萄糖舔的微观结构的影响。在雄性和雌性大鼠中，InsAb对发出的舔爆发的数量（动机和/或饱腹感的测量）没有影响，但在一系列的五个30分钟的测试中减少了舔爆发的大小（奖励幅度的测量）。这种效应持续超过微量注射测试阶段，并且显示依赖于InsAb治疗下而不是单独InsAb治疗下的先前调味葡萄糖消耗。这表明学习减少奖励价值，并与之前的发现一致，即InsAb阻止了风味-营养学习。InsAb对营养奖励作用的特异性通过未能影响调味的0.25%糖精溶液的任何舔舔参数来指示。最后，维持大鼠的“西方”饮食12周产生了减少舔爆裂大小的葡萄糖在雄性大鼠，但增加舔爆裂大小的女性。这些结果可能的影响味营养学习，适应不良的后果NAC胰岛素受体的不敏感性，和合理的参与不同的胰岛素调节机制NAC进行了讨论。
Insulin of pancreatic origin enters the brain where several regions express a high density of insulin receptors. Functional studies of brain insulin signaling have focused predominantly on hypothalamic regulation of appetite and hippocampal regulation of learning. Recent studies point to involvement of nucleus accumbens (NAc) insulin signaling in a diet-sensitive response to glucose intake and reinforcement of flavor-nutrient learning. The present study used NAc shell microinjection of an insulin inactivating antibody (InsAb) to evaluate effects on the microstructure of licking for flavored 6.1% glucose. In both male and female rats, InsAb had no effect on the number of lick bursts emitted (a measure of motivation and/or satiety), but decreased the size of lick bursts (a measure of reward magnitude) in a series of five 30-minute test sessions. This effect persisted beyond microinjection test sessions and was shown to depend on previous flavored glucose consumption under InsAb treatment rather than InsAb treatment alone. This suggests learning of diminished reward value and aligns with the previous finding that InsAb blocks flavor-nutrient learning. Specificity of the InsAb effect for nutrient reward was indicated by failure to affect any parameter of licking for flavored 0.25% saccharin solution. Finally, maintenance of rats on a ‘Western’ diet for twelve weeks produced a decrease in lick burst size for glucose in male rats, but an increase in lick burst size in females. Possible implications of these results for flavor-nutrient learning, maladaptive consequences of NAc insulin receptor subsensitivity, and the plausible involvement of distinct insulin-regulated mechanisms in NAc are discussed.
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DOI：
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