The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins
The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins
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DOI：
10.1110/ps.072803507
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发表时间：
2007-07-01
期刊：
影响因子：
8
通讯作者：
Wolberger, Cynthia
中科院分区：
文献类型：
--
作者：
Huyton, Trevor;Wolberger, Cynthia
肿瘤抑制蛋白pp32在许多乳腺癌和前列腺癌中高度过度表达，也与神经退行性疾病脊髓小脑性共济失调1型(SCA1)有关。Pp32是一种多功能蛋白，参与转录、凋亡、磷酸化和细胞周期进程的调节，后者通过与视网膜母细胞瘤肿瘤抑制因子的过度磷酸化形式相关联。我们已经确定了包含一个富含亮氨酸重复序列(LRR)结构域的N-末端pp32片段的结构，这为深入了解pp32(Anp32)蛋白家族的结构和生化性质提供了信息。
The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.