Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
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DOI：
10.1016/j.bmc.2007.11.039
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Chow, Christine S.
中科院分区：
文献类型：
--
作者：
Chang, Yu-Cheng;Herath, Jayatilake;Chow, Christine S.
在3-(3-氨基-3-羧丙基)天然修饰的基础上，合成了一系列3-取代尿苷和假尿苷衍生物。用圆二色谱和核磁共振波谱确定了它们的水溶液构象。官能团组成和链长对修饰核苷的正反构象分布影响很小。决定核苷构象的主要因素似乎是糖苷键(C-糖苷与N-糖苷)。(C)2007爱思唯尔有限公司。保留所有权利。
A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation. (C) 2007 Elsevier Ltd. All rights reserved.