Multivariate models of determinants of health-related quality of life in severe chronic obstructive pulmonary disease.
Multivariate models of determinants of health-related quality of life in severe chronic obstructive pulmonary disease.
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DOI：
10.1682/jrrd.2008.09.0127
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发表时间：
2009
影响因子：
--
通讯作者：
National Emphysema Treatment Trial Research Group
中科院分区：
文献类型：
--
作者：
Moy ML;Reilly JJ;Ries AL;Mosenifar Z;Kaplan RM;Lew R;Garshick E;National Emphysema Treatment Trial Research Group
重度慢性阻塞性肺疾病（COPD）患者和1秒用力呼气量（FEV 1）、运动能力和呼吸困难水平相似的患者具有广泛的健康相关生活质量（HRQL）。我们确定了COPD患者HRQL的独立决定因素。综合评估的生理，社会心理和临床变量从国家肺气肿治疗试验。通过医学结局研究36项简表身体健康总评（PCS）和心理健康总评（MCS）评分以及圣乔治呼吸问卷总分（SGRQ-TS）评估HRQL。在多元线性回归模型中，运动能力、呼吸困难、年龄、单次呼吸肺弥散量（一氧化碳预测百分比）和自我报告残疾是PCS评分的重要决定因素。呼吸困难、抑郁、抗抑郁药使用、日间嗜睡和教育是MCS评分的重要决定因素。既往参与肺康复、辅助供氧和口服皮质类固醇是SGRQ-TS的重要决定因素。尽管FEV 1、6分钟步行试验距离和呼吸困难与HRQL显著相关，但当考虑其他变量时，它们对HRQL的影响降低。更大的运动能力、先前参与肺康复和使用补充氧气与更好的HRQL显着相关。残疾的自我感觉、抑郁、呼吸困难、口服皮质类固醇和白天嗜睡与HRQL较差相关。为了优化HRQL，临床医生应该注意一些临床和生理因素。
Persons with severe chronic obstructive pulmonary disease (COPD) and similar levels of forced expiratory volume in 1 second (FEV1), exercise capacity, and dyspnea have a wide range of health-related quality of life (HRQL). We identified the independent determinants of HRQL in persons with COPD. Comprehensive assessments of physiological, psychosocial, and clinical variables from the National Emphysema Treatment Trial were used. HRQL was assessed by the Medical Outcomes Study 36-Item Short Form Physical Component Summary (PCS) and Mental Component Summary (MCS) scores and the St. George’s Respiratory Questionnaire total score (SGRQ-TS). In multivariate linear regression models, exercise capacity, dyspnea, age, single-breath diffusing capacity of the lung for carbon monoxide percent predicted, and self-report of being disabled were significant determinants of PCS score. Dyspnea, depression, antidepressant use, daytime sleepiness, and education were significant determinants of MCS score. Prior participation in pulmonary rehabilitation, supplemental oxygen use, and oral corticosteroid use were significant determinants of SGRQ-TS. Although FEV1, 6-minute walk test distance, and dyspnea significantly correlated with HRQL, their effects on HRQL were reduced when other variables were considered. Greater exercise capacity, prior participation in pulmonary rehabilitation, and use of supplemental oxygen were significantly associated with better HRQL. Self-perception of being disabled, depression, dyspnea, oral corticosteroid use, and daytime sleepiness were associated with worse HRQL. To optimize HRQL, clinicians should pay attention to a number of clinical and physiological factors.
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DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1164/ajrccm/140.6.1538
发表时间：
1989-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
JONES, PW;BAVEYSTOCK, CM;LITTLEJOHNS, P
通讯作者：
LITTLEJOHNS, P
影响因子：
24.3
作者：
Tashkin, D. P.;Celli, B.;Kesten, S.
通讯作者：
Kesten, S.
影响因子：
--
作者：
BECK, AT;ERBAUGH, J;MENDELSOHN, M
通讯作者：
MENDELSOHN, M
DOI：
10.1164/ajrccm/145.6.1321
发表时间：
1992-06-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
JONES, PW;QUIRK, FH;LITTLEJOHNS, P
通讯作者：
LITTLEJOHNS, P