Individualized proteomics.
Individualized proteomics.
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个体化蛋白质组学
DOI：
10.1016/j.jprot.2014.04.003
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发表时间：
2014
影响因子：
3.3
通讯作者：
Klose J
中科院分区：
文献类型：
--
作者：
Forler S;Klein O;Klose J
由于单核苷酸多态性 (SNP)，人类个体几乎所有基因都存在差异。当母本和父本基因组在 F1 个体中组合时，每个基因的两个等位基因代表任意组合。因此，个体的蛋白质表达表现出高度的变异性。此外，在蛋白质组内，蛋白质形成蛋白质-蛋白质相互作用的网络。由于多态性，这些网络在个体之间针对遗传或/和环境扰动的鲁棒性不同，个体之间的类型和组成不同，并且改变了蛋白质组网络中蛋白质的排列。作为一般性结论，人类个体对抗疾病的稳健性可能取决于蛋白质-蛋白质相互作用网络的结构和表达，由于“网络多态性”，该网络的功能效率在个体之间存在差异。本文是题为“纪念维塔利亚诺·帕里尼的蛋白质组学 20 年”特刊的一部分。客座编辑：Luca Bini、Juan J. Calvete、Natacha Turck、Denis Hochstrasser 和 Jean-Charles Sanchez。
Human individuals differ from one another in almost all of their genes due to single nucleotide polymorphisms (SNPs). When the maternal and the paternal genomes become combined in a F1 individual, the two alleles of each gene represent arbitrary combinations. In consequence, individuals show high variability in protein expression. Furthermore, within a proteome, the proteins form networks of protein–protein interactions. These networks differ between individuals in robustness against genetic or/and environmental perturbation due to polymorphisms, which differ in type and composition between individuals, and modify the arrangement of proteins in the proteomic network. As a general conclusion, the robustness of a human individual against diseases may depend on the structure and expression of the protein–protein interaction network that varies in its functional efficiency between individuals due to “network-polymorphisms”.This article is part of a Special Issue entitled: 20 years of Proteomics in memory of Vitaliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.