The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer
The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer
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DOI：
10.1007/s12032-010-9817-4
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发表时间：
2012-03-01
期刊：
影响因子：
3.4
通讯作者：
Sui, Li-Hua
中科院分区：
文献类型：
--
作者：
Huang, Ke-Jin;Sui, Li-Hua
本研究通过检测血管内皮生长因子C（VEGF C）、基质金属蛋白酶-2（MMP-2）、E-钙粘蛋白（E-cadherin）的表达，探讨VEGF C在卵巢癌转移中的作用机制及其与预后的关系。应用免疫组织化学方法检测227例卵巢癌患者卵巢组织中血管内皮生长因子C、基质金属蛋白酶-2和E-cadherin的表达。采用Pearson卡方检验、斯皮尔曼相关系数、单因素分析、多因素分析和Kaplan-Meier方法。血管内皮生长因子C、基质金属蛋白酶-2和E-cadherin在卵巢癌中的阳性表达率均高于交界性肿瘤和良性肿瘤（P < 0.01）。血管内皮生长因子C与基质金属蛋白酶2呈正相关（r = 0.665，P < 0.01），与E钙粘蛋白呈负相关（r =-0.185，P < 0.05）。单因素分析显示，临床分期、病理分级、淋巴结转移、残留病灶、化疗、腹水、血管内皮生长因子C、基质金属蛋白酶2对生存期有影响（P < 0.05）。考克斯多因素分析显示，除病理分级外，上述因素均为独立的预后因素。血管内皮生长因子C是评估卵巢癌预后的新指标。卵巢癌组织中血管内皮生长因子C的表达与基质金属蛋白酶2和E钙粘蛋白有关。
We investigated the correlation of vascular endothelial growth factor C, matrix metalloproteinase-2, E-cadherin to explore mechanisms of vascular endothelial growth factor C in the metastasis of ovarian cancer and the relationship of prognosis. We applied immunohistochemistry to investigate the expression of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in ovarian tissues of 227 patients. We adopted Pearson chi-square test, Spearman correlation coefficient, univariate analysis, multivariate analysis, and Kaplan-Meier method. The positive rate of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in ovarian cancer was higher than that in borderline and benign tumor (P < 0.01). Vascular endothelial growth factor C was positively correlated with matrix metalloproteinase-2 (r = 0.665, P < 0.01) while negatively with E-cadherin(r = -0.185, P < 0.05). Univariate analysis showed clinical stage, pathologic grade, lymphatic metastasis, residual disease, chemotherapy, ascites, vascular endothelial growth factor C, and matrix metalloproteinase-2-influenced survival time (P < 0.05). In Cox multivariate analysis, all the aforementioned factors were found to be independent prognostic factors except pathologic grade. Vascular endothelial growth factor C was a new target to assess the prognosis of ovarian cancer. The expression of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin.