Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli.
Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli.
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DOI：
10.1523/jneurosci.2747-10.2010
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发表时间：
2010-10-20
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影响因子：
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通讯作者：
Isaacson JS
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文献类型：
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作者：
Apicella A;Yuan Q;Scanziani M;Isaacson JS
梨状皮质中的锥体细胞整合来自多个嗅球二尖瓣和簇状 (M/T) 细胞的感觉信息。然而，属于不同嗅球肾小球的 M/T 细胞是否会聚到单个皮质细胞上尚不清楚。在这里，我们在嗅球皮层切片制备中使用钙成像，以提供梨状皮层中的神经元接收来自不同肾小球的会聚突触输入的直接证据。我们表明，不同肾小球通路的联合活性招募了锥体细胞群，而这些锥体细胞不能单独被单个通路激活。这种皮质神经元的协作募集仅发生在很窄的时间窗口内，并且是嗅觉皮层的固有特征，可以通过会聚的阈下突触输入的整合来解释。合作招募增强了部分重叠输入模式的皮质表征之间的差异，并可能有助于嗅觉辨别的初始步骤。
Pyramidal cells in piriform cortex integrate sensory information from multiple olfactory bulb mitral and tufted (M/T) cells. However, whether M/T cells belonging to different olfactory bulb glomeruli converge onto individual cortical cells is unclear. Here we use calcium imaging in an olfactory bulb-cortex slice preparation to provide direct evidence that neurons in piriform cortex receive convergent synaptic input from different glomeruli. We show that the combined activity of distinct glomerular pathways recruits ensembles of pyramidal cells that are not activated by the individual pathways alone. This cooperative recruitment of cortical neurons only occurs over a narrow time window and is a feature intrinsic to the olfactory cortex that can be explained by the integration of converging, subthreshold synaptic input. Cooperative recruitment enhances the differences between cortical representations of partially overlapping input patterns and may contribute to the initial steps of olfactory discrimination.