Synthesis and antifungal activity of coumarins and angular furanocoumarins
Synthesis and antifungal activity of coumarins and angular furanocoumarins
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DOI：
10.1016/s0968-0896(99)00138-8
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发表时间：
1999-09-01
影响因子：
3.5
通讯作者：
Daneshtalab, M
中科院分区：
文献类型：
--
作者：
Sardari, S;Mori, Y;Daneshtalab, M
当归是一种天然存在的具有抗真菌活性的呋喃香豆素，被认为是一类合成香豆素的先导结构，合成的香豆素和当归素衍生物对白色念珠菌、新生隐球菌、酿酒酵母和黑曲霉具有抗真菌活性。测定了几种香豆素对KB细胞的细胞毒作用。在本试验中，当归和几种有效的抗真菌药物被证明是无毒的。(C)1999爱思唯尔科学有限公司。保留所有权利。
Angelicin, a naturally occurring furanocoumarin, that showed antifungal activity, was considered as a lead structure for a group of synthetic coumarins, Antifungal activities of the synthesized coumarins and angelicin derivatives were reported against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae and Aspergillus niger. Human cell line cytotoxicity of several coumarins was evaluated against KB cells. Angelicin and several potent antifungals showed to be non-toxic in this assay. (C) 1999 Elsevier Science Ltd. All rights reserved.