A NEW NATRIURETIC PEPTIDE IN PORCINE BRAIN
A NEW NATRIURETIC PEPTIDE IN PORCINE BRAIN
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DOI：
10.1038/332078a0
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发表时间：
1988-03-03
期刊：
影响因子：
64.8
通讯作者：
MATSUO, H
中科院分区：
文献类型：
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作者：
SUDOH, T;KANGAWA, K;MATSUO, H
心房利钠肽（ANP）是一种由哺乳动物心房分泌的激素，调节体液和血压的稳态平衡1 -3。ANP样免疫反应性也存在于大脑中，这表明肽的功能作为一种神经肽4，5。我们在这里报告鉴定猪脑中的一种新的肽的26个氨基酸残基，引出一个药理学谱非常相似的ANP，如利尿钠，利尿和鸡直肠松弛活动。确定的肽的完整氨基酸序列与已知的ANP 1，3，6序列非常相似，但肯定不同，这表明两者的基因是不同的。因此，我们将肽命名为“脑钠肽”（BNP）。哺乳动物脑内BNP与ANP同时存在，提示ANP介导的生理功能可能是通过ANP和BNP双重机制调节的
Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant activities. The complete amino-acid sequence determined for the peptide is remarkably similar to but definitely distinct from the known sequence of ANP1,3,6, indicating that the genes for the two are distinct. Thus, we have designated the peptide 'brain natriuretic peptide' (BNP). The occurrence of BNP with ANP in mammalian brain suggests the possibility that the physiological functions so far thought to be mediated by ANP may be regulated through a dual mechanism involving both ANP and BNP