Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects
Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects
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DOI：
10.1161/01.hyp.27.4.854
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发表时间：
1996-04-01
期刊：
影响因子：
8.3
通讯作者：
Julius, S
中科院分区：
文献类型：
--
作者：
Jamerson, KA;Nesbitt, SD;Julius, S
血管紧张素转换酶抑制剂卡托普利可能会改善胰岛素敏感性，这表明抑制血管紧张素 II (Ang II) 可改善胰岛素抵抗。然而，全身给予血管紧张素II也与葡萄糖利用的改善而不是恶化有关。由于刺激和拮抗肾素-血管紧张素系统都会改善葡萄糖摄取，并且血管紧张素转换酶抑制剂和静脉注射Ang II都会引起骨骼肌血管舒张，因此可以想象，血流动力学因素而不是Ang II或血管紧张素转换酶抑制剂对骨骼、肌肉代谢的直接影响调节了葡萄糖利用率的增加。 Ang II 对完整人体骨骼肌中葡萄糖提取的直接影响尚未被描述。我们研究了局部输注 Ang II 对 20 名健康受试者前臂葡萄糖摄取的影响。通过使用分离的胰岛素灌注前臂模型，局部血浆胰岛素值比空腹值升高至 100 mU/mL，并在 90 分钟的输注期内维持在该水平。前 60 分钟单独使用胰岛素后，最后 30 分钟将 Ang II 注入肱动脉。动脉内 Ang II 输注导致前臂血流量减少 38%（P
Insulin sensitivity may be improved with the angiotensin-converting enzyme inhibitor captopril, suggesting o that inhibition of angiotensin II (Ang II) improves insulin resistance. However, the administration of systemic Ang II has also been associated with an improvement in rather than worsening of glucose utilization. Since both stimulating and antagonizing the renin-angiotensin system improve glucose uptake and both angiotensin-converting enzyme inhibitors and intravenous Ang II elicit skeletal muscle vasodilation, it is conceivable that hemodynamic factors rather than a direct effect of either Ang II or angiotensin-converting enzyme inhibitors on skeleta, muscle metabolism modulate the increase in glucose utilization. The direct effects of Ang II on glucose extraction in intact human skeletal muscle have not been previously described. We investigated the effects of local infusion of Ang II on glucose uptake in the forearm of 20 healthy subjects. With the use of the isolated insulin-perfused forearm model, local plasma insulin values were raised to 100 mU/mL over fasting values and maintained there for a 90-minute infusion period. After the first 60 minutes of insulin alone, Ang II was infused into the brachial artery for the last 30 minutes. Intra-arterial Ang II infusion caused a 38% decrease in forearm blood flow (P