The synthesis of dendritic EDOT-peptide conjugates and their multistimuli-responsive self-assembly into supramolecular nanorods and fibers in water.
The synthesis of dendritic EDOT-peptide conjugates and their multistimuli-responsive self-assembly into supramolecular nanorods and fibers in water.
复制标题
DOI：
10.1002/asia.201402271
复制
发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
P. Ahlers;Hendrik Frisch;Daniel Spitzer;Zuzana Vobecka;F. Vilela;Pol Besenius
中科院分区：
文献类型：
--
作者：
P. Ahlers;Hendrik Frisch;Daniel Spitzer;Zuzana Vobecka;F. Vilela;Pol Besenius
我们报道了两亲树枝状EDOT-多肽结合物的合成，并讨论了它们在水中的刺激响应性自组装成多阴离子纳米棒。为了扩展受阻生长的一般概念，即树状多肽疏水核心的扩大π-体系内的有吸引力的超分子相互作用被外围亲水相互作用所阻碍，我们证明了pH和离子强度的变化都能够独立地触发树枝状单体自组装成超分子纳米棒和纳米纤维。用圆二色谱和荧光光谱方法对这些转变进行了分析，并用透射电子显微镜对得到的超分子聚合物进行了表征。
We report the synthesis of amphiphilic dendritic EDOT-peptide conjugates and discuss their stimuli-responsive self-assembly into polyanionic nanorods in water. In order to expand the general concept of frustrated growth, whereby attractive supramolecular interactions within the enlarged π-system of the hydrophobic core of a dendritic peptide are hampered by repulsive interactions in the hydrophilic periphery, we show that changes in the pH and ionic strength are both able to independently trigger the self-assembly of the dendritic monomers into supramolecular nanorods and nanofibers. These transitions are analyzed using circular dichroism and fluorescence spectroscopic methods, and the resulting supramolecular polymers are characterized by transmission electron microscopy.