The primate amygdala and the neurobiology of social behavior: Implications for understanding social anxiety
The primate amygdala and the neurobiology of social behavior: Implications for understanding social anxiety
复制标题
DOI：
10.1016/s0006-3223(01)01307-5
复制
发表时间：
2002-01-01
影响因子：
10.6
通讯作者：
Amaral, DG
中科院分区：
文献类型：
--
作者：
Amaral, DG
杏仁核长期以来一直与情绪和社会行为的调解有关。由于很少有人类受试者选择性双侧杏仁核损伤，这些功能关联的证据大多来自动物受试者的研究。猕猴生活在复杂的、高度组织化的社会群体中，其特征是个体之间稳定的等级关系，这些个体参与复杂的社会交流形式，如面部表情。了解杏仁核在显示接近人类的社会复杂性水平的动物中的作用将有助于了解杏仁核在人类社会行为和精神病理学（如社交焦虑）中的作用。成年猕猴杏仁核的选择性双侧损伤导致对无生命物体缺乏恐惧反应和“社会不受约束”的行为模式。这些结果表明，杏仁核的功能作为一个保护性的“刹车”的参与对象或生物体，而评估潜在的威胁进行。他们还认为社交焦虑可能是杏仁核评估过程的失调或过度活跃。最后，最近来自发展研究的数据提出了一种可能性，至少在某些发展阶段，社会背景下的恐惧可能与对无生命物体的恐惧不同，可能是由不同的大脑区域控制的。(C)2002生物精神病学学会。
The amygdala has long been implicated in the mediation of emotional and social behaviors. Because there are very few human subjects with selective bilateral damage of the amygdala, much of the evidence for these functional associations has come from studies employing animal subjects. Macaque monkeys live in complex, highly organized social groups that are characterized by stable and hierarchical relationships among individuals who engage in complex forms of social communication, such as facial expressions. Understanding the role of the amygdala in animals that display a level of social sophistication approaching that of humans will help in understanding the amygdala's role in human social behavior and in psychopathology such as social anxiety. Selective bilateral lesions of the amygdala in mature macaque monkeys result in a lack of fear responses to inanimate objects and a "socially uninhibited" pattern of behavior. These results imply that the amygdala functions as a protective "brake" on engagement of objects or organisms while an evaluation of potential threat is carried out. They also suggest that social anxiety may be a dysregulation or hyperactivity of the amygdala's evaluative process. Finally, recent data from developmental studies raise the possibility that, at least at some developmental stages, fear in social contexts may be subserved by different brain regions than fear of inanimate objects. (C) 2002 Society of Biological Psychiatry.