On-step synthesis of a bifunctional BINOL ligand for the highly enantioselective cyanation of aliphatic aldehydes.
On-step synthesis of a bifunctional BINOL ligand for the highly enantioselective cyanation of aliphatic aldehydes.
复制标题
DOI：
10.1021/ol050660e
复制
发表时间：
2005-05
期刊：
影响因子：
5.2
通讯作者：
Ying‐chuan Qin;Lan Liu;L. Pu
中科院分区：
文献类型：
--
作者：
Ying‐chuan Qin;Lan Liu;L. Pu
[反应：见正文]已经开发了光学活性双官能BINOL配体（S）-3的有效一步合成。结果表明，（S）-3与Me_2AlCl的配合物对TMSCN与不同结构的脂肪醛的加成反应具有很高的对映选择性，也是最实用的催化剂之一。发现该手性配体具有显著的正非线性效应。
[reaction: see text] An efficient one-step synthesis of the optically active bifunctional BINOL ligand (S)-3 has been developed. It was found that (S)-3 in combination with Me2AlCl is a highly enantioselective catalyst for the addition of TMSCN to aliphatic aldehydes of diverse structures and is also among the most practical ones. A remarkable positive nonlinear effect was found for this chiral ligand.