Osteosarcoma: angiographic assessment of response to preoperative chemotherapy.
Osteosarcoma: angiographic assessment of response to preoperative chemotherapy.
复制标题
骨肉瘤：血管造影评估术前化疗的反应。
DOI：
10.1148/radiology.170.3.2916040
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发表时间：
1989
期刊：
影响因子：
19.7
通讯作者：
R. S. Benjamin
中科院分区：
文献类型：
--
作者：
C. Carrasco;C. Charnsangavej;A K Raymond;W. Richli;S. Wallace;S P Chawla;A. Ayala;J. A. Murray;R. S. Benjamin
辅助化疗可提高高级别骨肉瘤患者的生存率。术前化疗可以根据原发性肿瘤的反应来确定辅助化疗的有效药物。术前确定肿瘤反应具有治疗意义，血管造影术提供了一种比常规X线摄影或计算机断层扫描主观性更低的评估方法。在81例患者中，肿瘤血管的变化，如血管造影所示，在两个疗程后和术前化疗的最后几个疗程的时间与切除标本的组织学肿瘤坏死相关。通过血管造影，40%的组织学反应者和91%的无反应者在两个疗程的术前化疗后被确定。经过四个疗程的化疗，91%的反应，但只有50%的无反应者被确定血管造影。血管造影评估肿瘤血管，虽然不是绝对值，提供了一个有用的指导方针，以确定术前化疗策略。
Adjuvant chemotherapy prolongs the survival of patients with high-grade osteosarcoma. Preoperative chemotherapy allows identification of effective agents for adjuvant chemotherapy based on response of the primary tumor. Preoperative determination of tumor response has therapeutic implications, and angiography offers a less subjective means of assessing it than do conventional radiography or computed tomography. Changes in tumor vascularity, as seen angiographically, after two courses and at the time of the last of several courses of preoperative chemotherapy were correlated with histologic tumor necrosis of resected specimens in 81 patients. Angiographically, 40% of the histologic responders and 91% of the nonresponders were identified after two courses of preoperative chemotherapy. After a median of four courses of chemotherapy, 91% of the responders but only 50% of the nonresponders were identified angiographically. Angiographic assessment of tumor vascularity, although not of absolute value, offers a useful guideline for determining the preoperative chemotherapy strategy.