The role of WRNIP1 in genome maintenance.
The role of WRNIP1 in genome maintenance.
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DOI：
10.1080/15384101.2017.1282585
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发表时间：
2017-03-19
期刊：
影响因子：
--
通讯作者：
Enomoto T
中科院分区：
文献类型：
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作者：
Yoshimura A;Seki M;Enomoto T
WRNIP1与WRN解旋酶相互作用，而WRN解旋酶在早老性疾病Werner综合征中存在缺陷。WRNIP1属于AAA+ atp酶家族，从大肠杆菌到人类都是保守的。该蛋白在N端含有一个泛素结合锌指（UBZ）结构域，在中间区域含有一个atp酶结构域。除了WRN外，WRNIP1还与多种细胞通路中的蛋白相互作用，包括RAD18、单泛素化PCNA、DNA聚合酶δ、RAD51和ATMIN。WRNIP1的酵母同源物Mgs1可能作用于PCNA泛素化的下游，以调动DNA聚合酶δ。相比之下，WRNIP1在高等真核细胞中的功能仍然不清楚，尽管最近出现了关于WRNIP1在DNA交易中的作用的数据。在这里，我们首先描述了Mgs1在DNA交易中的功能。然后，我们描述了WRNIP1的各种特征，并根据最近对WRNIP1功能的研究讨论了其可能的作用。
WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. WRNIP1 belongs to the AAA+ ATPase family and is conserved from Escherichia coli to human. The protein contains an ubiquitin-binding zinc finger (UBZ) domain at the N terminus and an ATPase domain in the middle region. In addition to WRN, WRNIP1 interacts with proteins involved in multiple cellular pathways, including RAD18, monoubiquitylated PCNA, DNA polymerase δ, RAD51, and ATMIN. Mgs1, the yeast homolog of WRNIP1, may act downstream of ubiquitylation of PCNA to mobilize DNA polymerase δ. By contrast, the functions of WRNIP1 in higher eukaryotic cells remain obscure, although data regarding the roles of WRNIP1 in DNA transactions have emerged recently. Here, we first describe the functions of Mgs1 in DNA transaction. We then describe various features of WRNIP1 and discuss its possible roles based on recent studies of the function of WRNIP1.