VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
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DOI：
10.1007/s00441-003-0776-3
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发表时间：
2003-09
影响因子：
3.6
通讯作者：
M. Tjwa;A. Luttun;M. Autiero;P. Carmeliet
中科院分区：
文献类型：
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作者：
M. Tjwa;A. Luttun;M. Autiero;P. Carmeliet
血管通过提供氧气和营养物质对正常发育和生长至关重要。如在小鼠中的遗传靶向研究所示，斑马鱼和非洲爪蟾血管形成（或血管生成）是一个多步骤过程，其高度依赖于血管生成生长因子，如VEGF，VEGF家族的创始成员。VEGF与酪氨酸激酶受体VEGFR-1和VEGFR-2结合，并且VEGF或其受体的丧失导致发育期间的异常血管生成和致死性。相比之下，PlGF，该家族的另一个成员，仅与VEGFR-1结合，并且似乎仅对成人的病理性血管生成至关重要。然而，VEGFR-1和VEGFR-2在非血管细胞上的表达表明这些生长因子具有额外的生物学特性。事实上，VEGF家族及其受体决定许多器官的发育和体内平衡，包括呼吸系统、骨骼系统、造血系统、神经系统、肾脏和生殖系统，而与它们的血管作用无关。这些新的见解拓宽了这些“血管生成”生长因子的活性谱，并且当将这些生长因子用于血管和/或非血管目的时可能具有治疗意义。
Blood vessels are crucial for normal development and growth by providing oxygen and nutrients. As shown by genetic targeting studies in mice, zebrafish and Xenopus blood vessel formation (or angiogenesis) is a multistep process, which is highly dependent on angiogenic growth factors such as VEGF, the founding member of the VEGF family. VEGF binds to the tyrosine kinase receptors VEGFR-1 and VEGFR-2, and loss of VEGF or its receptors results in abnormal angiogenesis and lethality during development. In contrast, PlGF, another member of this family, binds only to VEGFR-1, and appears to be crucial exclusively for pathological angiogenesis in the adult. However, the expression of VEGFR-1 and VEGFR-2 on non-vascular cells suggests additional biological properties for these growth factors. Indeed, the VEGF family and its receptors determine development and homeostasis of many organs, including the respiratory, skeletal, hematopoietic, nervous, renal and reproductive system, independent of their vascular role. These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes.