Classical swine fever in pigs: recent developments and future perspectives
Classical swine fever in pigs: recent developments and future perspectives
复制标题
DOI：
10.1017/s1466252314000024
复制
发表时间：
2014-06-01
影响因子：
2.5
通讯作者：
Verma, Rishendra
中科院分区：
文献类型：
--
作者：
Chander, Vishal;Nandi, S.;Verma, Rishendra
猪瘟是世界范围内危害最大的猪瘟之一，在世界范围内引起高发病率和高死亡率。脑脊液临床表现的多样性和与其他疾病的相似性使得脑脊液难以明确诊断。由于存在属于三个系统发育组的一些不同的菌株，这种疾病进一步复杂化。先进的诊断技术可以检测临床样本中的抗原或抗体，从而实现适当和有效的控制计划。基于聚合酶链式反应的方法，包括便携式实时聚合酶链式反应，可以在几个小时内提供精确和准确的诊断，即使在护理点也是如此。在没有接种疫苗的国家，通过采取杜绝政策来控制疾病，而在流行国家，使用含有C毒株的减毒活疫苗有效地控制疾病。为了克服从接种疫苗的动物中区分受感染的动物的问题，已经开发了不同类型的有效程度不同的标记疫苗以及配套的诊断分析，在可预见的未来可能有助于控制甚至根除这种疾病。本审查旨在提供整个猪瘟的概况和现状，并特别提到印度的养猪业。
Classical swine fever (CSF) is one of the most devastating epizootic diseases of pigs, causing high morbidity and mortality worldwide. The diversity of clinical signs and similarity in disease manifestations to other diseases make CSF difficult to diagnose with certainty. The disease is further complicated by the presence of a number of different strains belonging to three phylogenetic groups. Advanced diagnostic techniques allow detection of antigens or antibodies in clinical samples, leading to implementation of proper and effective control programs. Polymerase chain reaction (PCR)-based methods, including portable real-time PCR, provide diagnosis in a few hours with precision and accuracy, even at the point of care. The disease is controlled by following a stamping out policy in countries where vaccination is not practiced, whereas immunization with live attenuated vaccines containing the 'C' strain is effectively used to control the disease in endemic countries. To overcome the problem of differentiation of infected from vaccinated animals, different types of marker vaccines, with variable degrees of efficacy, along with companion diagnostic assays have been developed and may be useful in controlling and even eradicating the disease in the foreseeable future. The present review aims to provide an overview and status of CSF as a whole with special reference to swine husbandry in India.