Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy
Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy
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DOI：
10.1002/art.1780400923
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发表时间：
1997-09-01
影响因子：
--
通讯作者：
Wicks, IP
中科院分区：
文献类型：
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作者：
Cooley, HM;Snowden, JA;Wicks, IP
Based on successful results in animal models, it has been proposed that high-dose myeloablative therapy followed by autologous bone marrow or stem cell transplantation (ABMT/ASCT) may cure autoimmune disease, The coexistence of autoimmune disease and hematologic malignancy provides an opportunity to examine the response of autoimmune disease to ABMT or ASCT. We describe 4 patients with autoimmune disease (3 with psoriasis and 1 with rheumatoid arthritis) and hematologic malignancy, In each patient, the autoimmune disease remitted posttransplantation, but, in 4 patients with long-term followup, it recurred at 8-24 months, The earliest relapse occurred in a patient treated with interferon-alpha. Our experience suggests that a single autograft with unpurged stem cells is unlikely to cure autoimmune disease, but that other strategies building on this approach are worthy of investigation.
