Radiation-induced eosinophilic, polymorphic, and pruritic eruption in a pig skin model.
Radiation-induced eosinophilic, polymorphic, and pruritic eruption in a pig skin model.
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DOI：
10.5625/lar.2015.31.4.204
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发表时间：
2015-12
影响因子：
2.9
通讯作者：
Lee SS
中科院分区：
文献类型：
--
作者：
Kim JS;Jang WS;Bae MJ;Park S;Lee SS
放疗相关性嗜酸性、多形性和嗜酸性疹（EPPER）可发生于癌症患者放疗后。在这项研究中，我们的特点是临床和组织病理学特征的猪皮肤，发展广泛的多态性和皮炎皮肤病变后，局部戈伊照射。照射后5-7周，猪出现瘙痒，照射后4-7周检测到嗜酸性粒细胞浸润真皮。辐照动物在处理后5-7周还显示外周嗜酸性粒细胞数量一过性增加。照射2-4周后引起脱屑，7周后脱屑逐渐消退。这些病理变化对应于在辐照的人皮肤中所见的那些，表明该模型可用于阐明EPPER的发病机制以及用于开发治疗和预防方法。
Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features of pig skin that developed widespread polymorphic and pruritic skin lesions following localized 50 Gy gamma-irradiation. The pigs developed pruritus 5-7 weeks after irradiation, and infiltration of the dermis by eosinophils was detected 4-7 weeks after irradiation. The irradiated animals also showed transiently increased numbers of peripheral eosinophils 5-7 weeks after treatment. Irradiation induced desquamation after 2-4 weeks, which and the desquamation gradually resolved after 7 weeks. These pathological changes correspond to those seen in irradiated human skin, indicating that this model could be useful for elucidating the pathogenesis of EPPER and for developing therapeutic and prophylactic methods.