The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry:: Estimates of radiation-related cancer risks
The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry:: Estimates of radiation-related cancer risks
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DOI：
10.1667/rr0553.1
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发表时间：
2007-04-01
影响因子：
3.4
通讯作者：
Veress, K.
中科院分区：
文献类型：
--
作者：
Cardis, E.;Vrijheid, M.;Veress, K.
进行了一项15国协作队列研究，以直接估计长期低剂量电离辐射后的癌症风险。分析包括407，391名核工业工人单独监测外部辐射和520万人年的随访。辐射剂量与全因死亡率之间存在显著相关性[超额相对风险（ERR）0.42/Sv，90% CI 0.07，0.79; 18，993例死亡]。这主要归因于所有癌症死亡率的剂量相关性增加（ERR/Sv 0.97，90% CI 0.28，1.77; 5233例死亡）。在研究的31种特定类型的恶性肿瘤中，发现与肺癌有显著相关性（ERR/Sv 1.86，90% CI 0.49，3.63; 1457例死亡）和临界显著性（P = 0.06）与多发性骨髓瘤的相关性（ERR/Sv 6.15，90%CI < 0，20.6; 83例死亡）和不明确和继发性癌症（ERR/Sv 1.96，90%CI-0.26，5.90; 328例死亡）。分层的就业时间有很大的影响ERR/Sv，反映了强大的健康工人幸存者在这些队列的影响。这是迄今为止对低剂量长期电离辐射照射的影响进行的最大规模的分析性流行病学研究。进一步的研究将是重要的，以更好地评估烟草和其他职业暴露在我们的风险估计中的作用。(c)2007年，辐射研究协会。
A 15-Country collaborative cohort study was conducted to provide direct estimates of cancer risk following protracted low doses of ionizing radiation. Analyses included 407,391 nuclear industry workers monitored individually for external radiation and 5.2 million person-years of follow-up. A significant association was seen between radiation dose and all-cause mortality [excess relative risk (ERR) 0.42 per Sv, 90% CI 0.07, 0.79; 18,993 deaths]. This was mainly attributable to a dose-related increase in all cancer mortality (ERR/Sv 0.97, 90% CI 0.28, 1.77; 5233 deaths). Among 31 specific types of malignancies studied, a significant association was found for lung cancer (ERR/Sv 1.86, 90% CI 0.49, 3.63; 1457 deaths) and a borderline significant (P = 0.06) association for multiple myeloma (ERR/Sv 6.15, 90% CI < 0, 20.6; 83 deaths) and ill-defined and secondary cancers (ERR/Sv 1.96, 90% CI -0.26, 5.90; 328 deaths). Stratification on duration of employment had a large effect on the ERR/Sv, reflecting a strong healthy worker survivor effect in these cohorts. This is the largest analytical epidemiological study of the effects of low-dose protracted exposures to ionizing radiation to date. Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates. (c) 2007 by Radiation Research Society.