Zipf's law in gene expression
Zipf's law in gene expression
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DOI：
10.1103/physrevlett.90.088102
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发表时间：
2003-02-28
影响因子：
8.6
通讯作者：
Kaneko, K
中科院分区：
文献类型：
--
作者：
Furusawa, C;Kaneko, K
使用来自各种生物体和组织（包括酵母、线虫、人类正常和癌组织以及胚胎干细胞）的基因表达数据库的数据，我们发现表达基因的丰度呈现指数接近-1的幂律分布;即，他们遵守齐普夫定律。此外，通过模拟一个简单的模型与细胞内的反应网络，我们发现，齐普夫定律的化学丰度是一个普遍的功能的细胞，这样的网络优化的效率和忠诚的自我繁殖。这些发现为活细胞中反应动力学的组织性质提供了新的见解。
Using data from gene expression databases on various organisms and tissues, including yeast, nematodes, human normal and cancer tissues, and embryonic stem cells, we found that the abundances of expressed genes exhibit a power-law distribution with an exponent close to -1; i.e., they obey Zipf's law. Furthermore, by simulations of a simple model with an intracellular reaction network, we found that Zipf's law of chemical abundance is a universal feature of cells where such a network optimizes the efficiency and faithfulness of self-reproduction. These findings provide novel insights into the nature of the organization of reaction dynamics in living cells.