Mechanisms of immunoglobulin action: observations on Kawasaki syndrome and RSV prophylaxis.
Mechanisms of immunoglobulin action: observations on Kawasaki syndrome and RSV prophylaxis.
复制标题
免疫球蛋白作用机制：川崎综合征和 RSV 预防的观察。
DOI：
10.1111/j.1600-065x.1994.tb00859.x
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发表时间：
1994
影响因子：
8.7
通讯作者：
Leung,DY
中科院分区：
文献类型：
--
作者：
Meissner,HC;Schlievert,PM;Leung,DY
适合静脉注射的丙种球蛋白的可用性。v. Ig)导致其应用于治疗越来越多的传染病和自身免疫性疾病。直到最近才阐明了γ球蛋白的一些具体作用机制。作用机制可大致分为中和特定毒素或微生物，或作为免疫调节。历史上，丙种球蛋白最初被用来增强对细菌、病毒或毒素的调理或中和作用。最近，人们描述了γ球蛋白的免疫调节功能，包括细胞因子产生的改变（Shimozato et al. 1990）、体外t细胞增殖的抑制（Antel et al. 1981）、体内t细胞活化的降低（Leung et al. 1987）、体外抗体分泌的抑制（Stohl 1986）、自然杀伤细胞活性的增加（Finberg et al. 1992）和抗体依赖性细胞毒性的增加（Finberg et al. 1992）。最近描述的一种免疫调节活性涉及到葡萄球菌超抗原活性的中和（Takei et al. 1993）。在本报告中，我们将描述对机理的研究
The availability of gamma globulin in a form suitable for intravenous use fi. v. Ig) has resulted in its application for treatment of an increasingly large number of infectious and autoimmune diseases. Only recently have some of the specific mechanisms of action of gamma globulin been elucidated. Mechanisms of action can be broadly classified as either neutralization of a specific toxin or microbe, or as immunomodulation. Historically, gamma globulins were first used to enhance opsonization or neutralization of bacteria, viruses or toxins. More recently immunomodulatory functions of gamma globulins have been described which include alterations in cytokine production (Shimozato et al. 1990), inhibition of T-cell proliferation in vitro (Antel et al. 1981), decreases in T-cell activation in vivo (Leung et al. 1987), inhibition of antibody secretion in vitro (Stohl 1986), increases in natural-killer cell activity (Finberg et al. 1992) and increases in antibodydependent cell cytotoxicity (Finberg et al. 1992). A recently described immunoregulatory activity of iv Ig involves neutralization of staphylococcal superantigen activity (Takei et al. 1993). In this report, we will describe studies on the mechan-