Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas
Frequent Allelic Loss of Dkk-1 Locus (10q11.2) is Related with Low Distant Metastasis and Better Prognosis in Head and Neck Squamous Cell Carcinomas
复制标题
DOI：
10.3109/07357900903095680
复制
发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Nagatsuka, Hitoshi
中科院分区：
文献类型：
--
作者：
Katase, Naoki;Gunduz, Mehmet;Nagatsuka, Hitoshi
头颈部鳞状细胞癌(HNSCC)是世界范围内常见的癌症。Dickkopf(DKK)-1基因可能作为肿瘤抑制基因(TSG)在多种恶性肿瘤中发挥作用。在这项研究中，我们进行了DKK-1杂合性缺失(LOH)分析，并首次研究了DKK-1杂合性缺失状态与临床病理参数的相关性。检测到相当高的杂合率(50%)。有趣的是，在DKK-1保留组中，远处转移较少，无病生存期较长。提示DKK-1在HNSCC的发生发展中可能起一定作用，并可能与远处转移有关。
Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.