Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men
Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men
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DOI：
10.1093/ajcn/87.5.1204
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Huang, Kuo-Chin
中科院分区：
文献类型：
--
作者：
Lin, Wen-Yuan;Chiu, Tai-Yuan;Huang, Kuo-Chin
背景：咀嚼槟榔与多种癌症、代谢综合征和2型糖尿病有关。然而，它是否与较高的心血管疾病 (CVD) 风险和全因死亡率相关尚不清楚。 目的：我们旨在调查咀嚼槟榔与 CVD 和全因死亡率之间的关系。 设计： 1998 年和 1999 年从台湾 4 个全国性健康检查中心招募了 56 116 名 20 岁以上男性参与者作为基线队列。 Cox 比例风险 采用回归分析来估计槟榔咀嚼者在 8 年随访期间的 CVD 相对风险 (RR) 和全因死亡率。结果：随访期间共有 1549 例死亡，其中 309 例死于 CVD。调整年龄、体重指数、糖尿病、高血压、血脂、吸烟、饮酒、体力活动、收入和教育水平后，以前咀嚼槟榔者的心血管疾病和全因死亡率的RR（95％CI）分别为1.56（1.02，2.38）和1.40（1.17，1.68），而现在咀嚼槟榔者的RRs（95％CI）分别为2.02（1.31，1.68）。 与从未咀嚼过槟榔的人相比，分别为 3.13）和 1.40（1.16、1.70）。目前和以前经常咀嚼槟榔的人比现在和以前吸烟者的 CVD 死亡风险更高（RR：2.10；P < 0.05）。咀嚼槟榔频率越高，CVD 和全因死亡率越高。结论：台湾男性咀嚼槟榔与 CVD 和全因死亡率较高风险独立相关。定期筛查槟榔咀嚼史可能有助于防止未来出现过多死亡。对于当前的咀嚼者来说，迫切需要制定一项反槟榔咀嚼计划。
Background: Betel nut chewing is related to several kinds of cancer, metabolic syndrome, and type 2 diabetes. Whether it is associated with a greater risk of cardiovascular disease (CVD) and all-cause mortality, however, remains unclear.Objective: We aimed to investigate the association between betel nut chewing and CVD and all-cause mortality.Design: A baseline cohort of 56 116 male participants >= 20 y old were recruited from 4 nationwide health screening centers in Taiwan in 1998 and 1999. Cox proportional hazards regression analyses were used to estimate the relative risks (RRs) of CVD and all-cause mortality for betel nut chewers during an 8-y follow-up period.Results: There were 1549 deaths during the follow-up period, 309 of which were due to CVD. After adjustment for age, body mass index, diabetes, hypertension, lipids, smoking, alcohol consumption, physical activity, income, and education level, the RRs (95% CI) of CVD and all-cause mortality among the former betel nut chewers were 1.56 (1.02, 2.38) and 1.40 (1.17, 1.68), respectively, and those among current chewers were 2.02 (1.31, 3.13) and 1.40 (1.16, 1.70), respectively, compared with persons who had never chewed betel quid. Current and former betel nut chewers had a higher risk of CVD mortality (RR: 2.10; P < 0.05) than did current and former smokers. Greater frequency of betel nut chewing was associated with greater CVD and all-cause mortality.Conclusions: Betel nut chewing was independently associated with a greater risk of CVD and all-cause mortality in Taiwanese men. Regular screening for betel nut chewing history may help prevent excess deaths in the future. An anti-betel nut chewing program is urgently warranted for current chewers.