Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues
Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues
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DOI：
10.1038/ni.2534
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发表时间：
2013-03-01
影响因子：
30.5
通讯作者：
Spits, Hergen
中科院分区：
文献类型：
--
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
先天性淋巴样细胞（inate lymphoid cells，ILC）是先天性免疫的效应细胞和组织建模的调节细胞。最近鉴定的ILC群体具有类似于辅助T细胞亚群T（H）2、T（H）17和T（H）22的细胞因子表达模式。在这里，我们描述了一个独特的ILC子集类似于T（H）1细胞，我们称之为“ILC 1”。ILC 1细胞表达转录因子T-bet，并通过产生干扰素-γ（IFN-γ）对白细胞介素12（IL-12）作出反应。ILC 1细胞不同于自然杀伤（NK）细胞，因为它们缺乏穿孔素、颗粒酶B和NK细胞标志物CD 56、CD 16和CD 94，并且可以在IL-12的影响下从ROR γ t（+）ILC 3发育。在克罗恩病患者发炎的肠道中，ILC 1亚群的频率要高得多，这表明这些产生IFN-γ的ILC 1细胞在肠道粘膜炎症的发病机制中起作用。
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-gamma (IFN-gamma). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from ROR gamma t(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-gamma-producing ILC1 cells in the pathogenesis of gut mucosal inflammation.