HIV DNA Vaccine: Stepwise Improvements Make a Difference.
HIV DNA Vaccine: Stepwise Improvements Make a Difference.
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DOI：
10.3390/vaccines2020354
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发表时间：
2014-05-14
期刊：
影响因子：
7.8
通讯作者：
Pavlakis GN
中科院分区：
文献类型：
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作者：
Felber BK;Valentin A;Rosati M;Bergamaschi C;Pavlakis GN
目前，质粒DNA作为HIV/AIDS疫苗的主要障碍是其表达量低和递送效率低。本文综述了近30年来DNA疫苗研究的进展。DNA疫苗接种，无论是单独还是与其他方法结合，都有可能成为一种快速、安全、有效的艾滋病疫苗平台。最近的临床试验表明其翻译到临床的可行性。
Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.