Cardiac arrhythmias modelled by Cai-inactivated Ca2+ channels.
Cardiac arrhythmias modelled by Cai-inactivated Ca2+ channels.
复制标题
由 Cai 失活的 Ca2 通道模拟的心律失常。
DOI：
10.1007/bf00204756
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发表时间：
1989
影响因子：
1.9
通讯作者：
Chay,TR
中科院分区：
文献类型：
--
作者：
Lambert,MH;Chay,TR
建立了以膜电位和细胞内钙浓度为两个动态变量的心肌细胞模型。该模型应用于简单的细胞系统，以研究其行为作为模型参数的函数。在两个偶联起搏器细胞的系统中观察到合理的夹带。模拟了细胞膜电位和细胞内钙浓度通过薄片的传播。行为暗示马戏运动心动过速观察。
A model of cardiac cells incorporating the membrane potential and the intracellular calcium concentration as the two dynamical variables is developed. This model is applied to simple systems of cells to investigate its behavior as a function of the model parameters. Rational entrainment is observed in systems of two coupled pacemaker cells. The propagation of the membrane potential and intracellular calcium concentration through a sheet is simulated. Behavior suggestive of circus movement tachycardias is observed.