Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
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DOI：
10.1161/atvbaha.110.218131
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
2010 Platelet Colloquium Participants
中科院分区：
文献类型：
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作者：
Williams MS;Weiss EJ;Sabatine MS;Simon DI;Bahou WF;Becker LC;Parise LV;Dauerman HL;French PA;Smyth SS;Becker RC;2010 Platelet Colloquium Participants
通过深入了解与特定基因型相关的风险和可能的益处，了解遗传对血小板功能的贡献可能会对个性化血小板定向药物治疗产生深远的临床影响。本文是对 2010 年 1 月举行的第五届血小板受体表达和功能遗传调控相关演讲的综合总结。本文还补充了文献中的其他重点内容，涵盖 1) 确定遗传变异与血小板低反应和高反应表型之间关系的方法和证据，2) 这些多态性对临床反应的影响 抗血小板治疗，3) 血小板功能/基因检测在指导抗血小板治疗中的作用。
Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering 1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, 2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and 3) the role of platelet function/genetic testing in guiding antiplatelet therapy.