Critical role of FOXO3a in carcinogenesis.
Critical role of FOXO3a in carcinogenesis.
复制标题
FOXO3a 在致癌过程中的关键作用
DOI：
10.1186/s12943-018-0856-3
复制
发表时间：
2018-07-25
期刊：
影响因子：
37.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu Y;Ao X;Ding W;Ponnusamy M;Wu W;Hao X;Yu W;Wang Y;Li P;Wang J
FOXO3a是FOXO叉头转录因子亚家族的成员，参与多种细胞过程，包括细胞凋亡、增殖、细胞周期进展、DNA损伤和肿瘤发生。它还对几种细胞应激做出反应，如紫外线照射和氧化应激。FOXO3a的功能受一个复杂的过程网络调控，包括microRNAs转录后抑制(MiRNAs)、翻译后修饰(PTM)和蛋白质-蛋白质相互作用。FOXO3a广泛与多种疾病有关，特别是乳腺癌、肝癌、结肠癌、前列腺癌、膀胱癌和鼻咽癌。越来越多的证据表明，FOXO3a在癌症中起着肿瘤抑制因子的作用。FOXO3a基因突变或FOXO3a蛋白胞质滞留在癌细胞系中经常失活。而它的失活与癌症的发生和发展有关。在实验研究中，FOXO3a的过表达抑制了癌细胞的增殖、致瘤潜力和侵袭力，而沉默FOXO3a导致对肿瘤形成的保护显著减弱。FOXO3a在正常生理和癌症发展中的作用对制定有效的癌症治疗策略提出了巨大的挑战。在这篇综述中，我们总结了最近的发现和对FOXO3a在癌症发生和进展中的影响的当前理解的概述。
FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress. The function of FOXO3a is regulated by a complex network of processes, including post-transcriptional suppression by microRNAs (miRNAs), post-translational modifications (PTMs) and protein–protein interactions. FOXO3a is widely implicated in a variety of diseases, particularly in malignancy of breast, liver, colon, prostate, bladder, and nasopharyngeal cancers. Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer. In experimental studies, overexpression of FOXO3a inhibits the proliferation, tumorigenic potential, and invasiveness of cancer cells, while silencing of FOXO3a results in marked attenuation in protection against tumorigenesis. The role of FOXO3a in both normal physiology as well as in cancer development have presented a great challenge to formulating an effective therapeutic strategy for cancer. In this review, we summarize the recent findings and overview of the current understanding of the influence of FOXO3a in cancer development and progression.
登录
查看更多内容
影响因子：
4.8
作者：
Allard, David;Figg, Nichola;Littlewood, Trevor D.
通讯作者：
Littlewood, Trevor D.
影响因子：
4.4
作者：
Anderson, MJ;Viars, CS;Arden, KC
通讯作者：
Arden, KC
影响因子：
18.2
作者：
Galasso, Gennaro;De Rosa, Roberta;Chiariello, Massimo
通讯作者：
Chiariello, Massimo
影响因子：
5.3
作者：
Delpuech, Oona;Griffiths, Beatrice;Schulze, Almut
通讯作者：
Schulze, Almut
影响因子：
--
作者：
Ge, Yun-Fei;Sun, Jun;Shao, Jun-Fei
通讯作者：
Shao, Jun-Fei